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KMID : 0880520090450030145
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Chonnam Medical Journal
2009 Volume.45 No. 3 p.145 ~ p.153
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Recent Advances in Gene Therapy Targeted to Intracellular Calcium Transport for Heart Failure
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Seong Mun-Hyuk
Bae Jang-Wahn
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Abstract
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Heart failure is a major health problem in developed countries. As a result of the increased prevalence of hypertension, diabetes mellitus, and chronic renal failure and the improved initial survival of patients with acute myocardial infarction or chronic ischemic heart disease, the prevalence of heart failure is continuously increasing. Therefore, the socioeconomic burden of controlling heart failure in developed countries is steeply increasing as well. Even with advanced treatment options, e.g., pharmacotherapy including betaadrenergic blocking agents, renin-angiotensin system blockers, mechanical cardiac assist devices, cardiac resynchronization therapy, and finally, cardiac transplantation, the 5-year survival rate of advanced heart failure is still about 50%. Other than the above classic treatment modalities in heart failure, cell or gene therapy has been recommended as a new, investigational treatment option for this disease. With increasing knowledge about the molecular and genetic mechanisms of heart failure, gene delivering systems, and the development of biocompatible biomaterial gene transfection molecules, gene therapy has fabulous academic interest for treating chronic, advanced, non-optional heart failure patients.
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KEYWORD
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Gene therapy, Heart failure, Calcium
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